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Updated: Jun 9, 2025

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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Challenges and Considerations in Modern Adjuvant Therapy Trials in Renal Cell Carcinoma: A Call to Power

Daniel D Shapiro1, Pavlos Msaouel2

  • 1Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Division of Urology, William S. Middleton Memorial Veterans Hospital, Madison, WI, USA.

European Urology
|October 29, 2024
PubMed

Insights

Identifying effective adjuvant therapies for renal cell carcinoma (RCC) is difficult, even with immune checkpoint inhibitors. Improving trial design by focusing on high-risk patients and increasing sample size is key for accurate efficacy assessments.

Area of Science:

  • Oncology
  • Nephrology
  • Clinical Trial Design

Background:

  • Adjuvant therapy for renal cell carcinoma (RCC) faces challenges in identifying effective treatments.
  • Immune checkpoint inhibitors have advanced RCC treatment but their adjuvant role requires further investigation.

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