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Risk factors for bacteremia in infants with urinary tract infection
Hsiang-Chin Chiu1, Chih-Chieh Yang1, Cai-Sin Yao2
1Department of Pediatrics, Pingtung Veterans General Hospital, Pingtung, Taiwan; Division of Pediatric Neonatology, Department of Pediatrics, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Pediatrics and Neonatology
|October 29, 2024
Summary
Infants with urinary tract infections (UTIs) who have underlying diseases or high C-reactive protein (CRP) levels are at increased risk for bacteremia. Early identification of these risk factors is vital for timely treatment.
Area of Science:
- Pediatrics
- Infectious Diseases
- Neonatology
Background:
- Urinary tract infections (UTIs) in infants can lead to serious complications like bacteremia, septic shock, and bacterial meningitis.
- Prompt identification of risk factors for bacteremia in infants with UTI is essential for preventing adverse outcomes.
Purpose of the Study:
- To identify independent risk factors for bacteremia in infants diagnosed with UTI.
- To improve early detection and management of bacteremic UTIs in infants.
Main Methods:
- A retrospective study involving 632 infants (≤12 months) with UTI between 2015 and 2021.
- Analysis of demographic, clinical, and laboratory data for 20 infants with concurrent bacteremia.
- Binary logistic regression used to determine independent risk factors for bacteremic UTI.
Main Results:
- Independent risk factors for bacteremic UTI included positive underlying disease (e.g., congenital anomalies of kidney and urinary tract [CAKUT], prematurity), C-reactive protein (CRP) > 8 mg/dL, lower body weight, and positive urinary nitrite.
- These factors significantly increased the likelihood of bacteremia in infants with UTI.
Conclusions:
- Infants with UTI presenting with underlying diseases or elevated CRP levels (>8 mg/dL) require heightened clinical suspicion for bacteremia.
- Awareness of these risk factors can guide prompt diagnostic and therapeutic interventions in at-risk infants.
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