Related Experiment Videos
Serum kinetics of intraperitoneal moxalactam
Archives of Surgery (Chicago, Ill. : 1960)
|March 1, 1986
Summary
Continuous intraperitoneal antibiotic administration, like moxalactam, achieves sustained serum levels in dogs with peritonitis. This suggests that systemic antibiotic therapy may not be necessary when using intraperitoneal lavage.
Area of Science:
- Pharmacology
- Infectious Diseases
- Veterinary Medicine
Background:
- Continuous intraperitoneal antibiotic administration is a recommended treatment for peritonitis.
- The need for concurrent systemic antibiotic administration alongside intraperitoneal therapy is not well-defined.
Purpose of the Study:
- To investigate the pharmacokinetics of moxalactam in dogs under various administration routes and conditions relevant to peritonitis treatment.
- To determine if systemic antibiotic administration is necessary when using continuous intraperitoneal antibiotic therapy for peritonitis.
Main Methods:
- Moxalactam serum kinetics were evaluated in dogs using different administration protocols: intravenous, intraperitoneal, and hourly peritoneal lavage.
- Specific protocols included varying doses, timing relative to peritonitis onset, and repeated lavage exchanges.
Main Results:
- Intraperitoneal moxalactam administration resulted in more sustained serum concentrations compared to intravenous administration.
- Repeated peritoneal lavage exchanges led to progressively increasing serum antibiotic levels.
- Peritonitis itself was associated with statistically higher serum antibiotic concentrations than in control subjects.
Conclusions:
- Continuous intraperitoneal antibiotic administration, particularly with lavage, can achieve effective and sustained serum levels.
- Concomitant systemic antibiotic therapy may not be required when utilizing continuous intraperitoneal antibiotic lavage for peritonitis treatment.