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Monitoring Stub1-Mediated Pexophagy
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AAA+ ATPase chaperone p97/VCPFAF2 governs basal pexophagy

Fumika Koyano1, Koji Yamano2, Tomoyuki Hoshina2

  • 1Department of Biomolecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University (TMDU) (Medical Research Laboratory, Institute of Integrated Research, Institute of Science Tokyo), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan. koyano-fm.biom@tmd.ac.jp.

Nature Communications
|October 30, 2024
PubMed
Summary

Mammalian FAF2/UBXD8 maintains peroxisomal homeostasis by controlling peroxisomal membrane protein turnover. Its absence triggers pexophagy, the autophagic clearance of peroxisomes, highlighting a role in regulating organelle stability.

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