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The THINC-it tool: temporal sensitivity to change over time.

Na Zhu1, Jia Huang2, YouSong Su2

  • 1Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, China.

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|October 30, 2024
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Summary

Cognitive dysfunction in bipolar depression (BD-D) is common, but the THINC-it tool shows it remains stable over time in Chinese patients. This validated tool reliably measures cognitive changes in BD-D, distinguishing affected individuals from healthy controls.

Keywords:
Bipolar depressionCognitive impairmentTHINC-it

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Cognitive dysfunction is a core feature of Bipolar Depression (BD-D), yet its assessment and treatment remain limited.
  • Evaluating temporal sensitivity to change in cognitive function is crucial for understanding BD-D progression and treatment efficacy.
  • The THINC-it tool is a potential instrument for continuous and reliable cognitive assessment in clinical settings.

Purpose of the Study:

  • To longitudinally evaluate the temporal sensitivity and reliability of the THINC-it tool in a Chinese cohort of patients with Bipolar Depression (BD-D).
  • To assess the stability of cognitive function over time in BD-D patients using the THINC-it tool.
  • To determine if the THINC-it tool can reliably differentiate cognitive impairment between BD-D patients and healthy controls.

Main Methods:

  • A longitudinal clinical trial involving 120 patients with BD-D and 100 healthy controls (HC).
  • Participants were assessed over 8 weeks using the THINC-it tool, alongside the 17-item Hamilton Depression Rating Scale (HAMD-17) and Young Mania Rating Scale (YMRS).
  • Psychometric analysis, including general linear models and longitudinal analysis, was performed, controlling for confounding factors like age, gender, education, and HAMD-17 scores.

Main Results:

  • No significant time-related differences in cognitive function variances were found in BD-D patients over the 8-week period (P > 0.05).
  • Longitudinal analysis confirmed no significant changes in cognitive impairment over time after adjusting for confounding factors (P > 0.05).
  • Significant differences in cognitive performance were observed between BD-D patients and HC across several THINC-it subtests (Spotter, Codebreaker, Trails, PDQ-5-D) and the total composite score (P < 0.05).

Conclusions:

  • The THINC-it tool demonstrates temporal stability and sensitivity to group differences in cognitive function among Chinese patients with Bipolar Depression.
  • The findings support the feasibility and reliability of the THINC-it tool for iterative cognitive evaluation in BD-D.
  • This study highlights the THINC-it tool's utility in identifying and monitoring cognitive dysfunction in BD-D, aiding clinical assessment and treatment strategies.