Lead encephalopathy presenting as status epilepticus: a case report
Iqra J Kamal1,2, Trevor Cerbini2,3, Amanda Clouser4,5
1Children's Hospital of New Jersey at Newark Beth Israel Medical Center, 201 Lyons Ave, Newark, NJ, 07112, US.
Insights
Severe lead encephalopathy in a child was successfully treated with dual chelation therapy. This case highlights effective treatment strategies and proper dosing for lead poisoning in pediatric patients.
Area of Science:
- Pediatric Neurology
- Toxicology
- Environmental Health
Background:
- Lead encephalopathy is a rare but severe consequence of lead intoxication.
- Physicians may face challenges in diagnosing and managing severe lead toxicity due to its rarity.
- A case of a 4-year-old girl with severe microcytic anemia and elevated lead levels is presented.
Background:
Lead encephalopathy, while thankfully rare, is a devastating and potentially fatal consequence of lead intoxication. Owing to successful public health measures, severe lead toxicity is not often encountered by most practicing physicians in the United States, making both its recognition and management challenging. A case study of a 4-year-old female presenting in refractory status epilepticus, found to have severe microcytic anemia and lead level > 100 mcg/dL.
Case Presentation:
We report a case of a 4-year-old girl who presented with refractory seizures, severe microcytic anemia, and a history of developmental delay who was ultimately diagnosed with lead encephalopathy, requiring multiple courses of calcium disodium ethylenediaminetetraacetic acid (EDTA) and succimer for rebounding lead levels.
Conclusion:
Rapid recognition and appropriate management is essential to ensure neurologically intact survival. This case documents one of the first cases of successful lead chelation after multiple courses of calcium disodium EDTA and succimer dual therapy since the removal of dimercaprol from the United States market. This case also highlights the importance of using body surface area dosing for chelation therapy in order to prevent under-dosing in young children.
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