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Causal association between gastrointestinal diseases and coronary artery disease: a bidirectional Mendelian

Zhuoxi Wang1, Jifang Ban1, Yabin Zhou2

  • 1First Clinical Medical School, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China.

Frontiers in Endocrinology
|October 30, 2024
PubMed

Insights

Genetic susceptibility to gastrointestinal disorders may increase the risk of coronary artery disease (CAD) and heart failure (HF). This highlights the importance of preventing CAD in individuals with gastrointestinal disorders.

Area of Science:

  • Genetics
  • Cardiology
  • Gastroenterology

Background:

  • Coronary artery disease (CAD) is a leading global cause of mortality.
  • Gastrointestinal disorders (GDs) are increasingly recognized as potential contributors to CAD.
  • The causal relationship between GDs and CAD requires further investigation.

Purpose of the Study:

  • To investigate the potential causal relationship between various gastrointestinal disorders (GDs) and coronary artery disease (CAD).
  • To explore the association between GDs and heart failure (HF) as well.
  • To determine if these relationships are bidirectional.

Main Methods:

  • Utilized two-sample Mendelian randomization (MR) analysis.
  • Employed single-nucleotide polymorphisms (SNPs) for 22 GDs as instrumental variables from GWAS datasets.
  • Conducted univariable MR (UVMR), multivariable MR (MVMR), and bidirectional MR analyses using data from UK Biobank, FinnGen, and other GWAS.

Main Results:

  • Genetic liability to gastroesophageal reflux disease showed a positive association with both CAD and HF risk.
  • Genetic liability to celiac disease was associated with increased risk of CAD and HF, persisting after MVMR.
  • Mutually causal associations were observed between CAD and celiac disease.

Conclusions:

  • Genetic predisposition to certain GDs may causally increase the risk of developing CAD and HF.
  • Findings underscore the importance of proactive CAD prevention strategies in patients diagnosed with GDs.
  • This research provides evidence for a genetic link between specific gastrointestinal conditions and cardiovascular diseases.
Abstract

Keywords:
Mendelian randomizationcausal inferencecoronary artery diseasegastrointestinal diseasesstatistical method

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