Evidence-based orthobiologic practice: Current evidence review and future directions
Madhan Jeyaraman1,2, Naveen Jeyaraman1, Swaminathan Ramasubramanian3
1Department of Orthopedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nadu, India.
World Journal of Orthopedics
|October 30, 2024
Summary
Orthobiologics, like platelet-rich plasma and stem cells, enhance healing for musculoskeletal injuries. Further research and standardized protocols are needed for optimal clinical application of these regenerative therapies.
Area of Science:
- Orthopedics and regenerative medicine
- Biologically derived therapies
Background:
- Orthobiologics, including platelet-rich plasma, mesenchymal stem cells, and stromal vascular fraction (SVF), are increasingly used for musculoskeletal conditions.
- These therapies offer alternatives to surgery for injuries and degenerative diseases like osteoarthritis and tendon issues.
Discussion:
- Evidence supports orthobiologics for various conditions, but treatment inconsistencies and outcomes persist.
- The market is growing, driven by novel therapies like adipose-derived stem cells and SVF, and demand for minimally invasive options.
Key Insights:
- Orthobiologics show promise in enhancing the body's natural healing processes.
- Standardized research and regulatory clarity are crucial for widespread adoption.
Outlook:
- Future advancements include improved delivery systems, personalized medicine, and novel cell sources like induced pluripotent stem cells.
- Collaboration is essential to ensure safe and effective clinical use of orthobiologics.
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