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Related Experiment Video

Updated: Jun 9, 2025

Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
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Gold Nanoclusters as High Resolution NIR-II Theranostic Agents.

Nancy Sharma1, Walaa Mohammad2, Xavier Le Guével2

  • 1Institute of Nano Science and Technology, Sector 81, Knowledge City, Mohali 140306, Punjab, India.

Chemical & Biomedical Imaging
|October 30, 2024
PubMed
Summary

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Atomically precise gold nanoclusters (AuNCs) offer tunable near-infrared II (NIR-II) emission for advanced bioimaging. These nanomaterials show promise for high-resolution diagnostics and theranostics, though clinical translation requires further development.

Area of Science:

  • Nanomaterials Science
  • Biomedical Imaging
  • Optical Spectroscopy

Background:

  • Atomically precise quasi-molecular gold nanoclusters (AuNCs) possess unique, stable, and tunable optical properties.
  • Structure-engineering of AuNCs modulates surface electronic states for long-wavelength photoluminescence, especially in the NIR-II window (1000-1700 nm).

Purpose of the Study:

  • To review the origin of NIR-II emission in rationally designed AuNCs.
  • To discuss the application of AuNCs in high-resolution imaging and tumor theranostics.
  • To highlight challenges and future scope for clinical translation of AuNCs.

Main Methods:

  • Discussion of structure-property relationships in AuNCs for NIR-II emission.
  • Review of applications in high-resolution imaging of vasculature, tissues, and pathological conditions.

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  • Summary of recent advancements in AuNCs for tumor theranostics.

    • Main Results:

    • AuNCs exhibit tunable NIR-II emission, enabling enhanced optical imaging with higher resolution and deeper tissue penetration.
    • NIR-II emitting AuNCs facilitate real-time in vivo imaging for disease progression monitoring.
    • AuNCs are increasingly employed in tumor theranostics, combining diagnostic and therapeutic capabilities.

    Conclusions:

    • Rationally designed AuNCs are powerful tools for advanced biomedical imaging and theranostics.
    • Further improvements in optical properties and addressing challenges are crucial for clinical translation.
    • AuNCs hold significant potential to revolutionize optical imaging and disease management.