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The Interplay of Inflammatory Bowel Disease (IBD) and Diabetes in Pediatrics: A Systematic Review
Amir Fayyaz Shaikh Sardar Muhammad1, Talal Mohammad K Abdulkareem2, Abdullah Enayatullah Bakheet Alharbi3
1Pediatrics, Maternity and Children Hospital, Arar, SAU.
Insights
This study reviewed pediatric diabetes and inflammatory bowel disease (IBD) cases. No direct link was found between type 1 diabetes (T1D) and childhood IBD, but more research is needed.
Area of Science:
- Pediatric Endocrinology
- Gastroenterology
- Autoimmune Diseases
Background:
- Co-occurrence of diabetes and inflammatory bowel disease (IBD) in children presents unique clinical challenges.
- Understanding the relationship between these conditions is crucial for effective pediatric patient management.
Purpose of the Study:
- To summarize existing literature on the clinical management of pediatric patients with both diabetes and IBD.
- To identify the prevalence and potential associations between type 1 diabetes (T1D) and childhood IBD.
Main Methods:
- Comprehensive literature search conducted across major electronic databases (ScienceDirect, PubMed, Cochrane Library, Scopus).
- Data extraction and evaluation performed by two independent reviewers.
- Systematic review of five studies encompassing a large pediatric cohort.
Main Results:
- Analysis of 79,878 patients revealed a low prevalence of co-occurring T1D and IBD.
- Three studies identified 17 cases of T1D in 2432 children with IBD (0.7%).
- Two studies found 83 cases of IBD in 77,446 children with T1D (0.1%); no significant association between T1D and childhood IBD was established.
Conclusions:
- The study highlights a poorly understood connection between pediatric diabetes and IBD.
- No direct link was found between type 1 diabetes and childhood IBD in the reviewed literature.
- Significant gaps in current research necessitate further investigation into the complex interplay of these conditions and the development of tailored management strategies for affected children.
Abstract:
The main objective of this study is to provide insights into the clinical problems and considerations in managing pediatric patients with both diabetes and inflammatory bowel disease (IBD) by summarizing the available information. We conducted a comprehensive search across electronic resources, including ScienceDirect, PubMed, Cochrane Library, and Scopus. Two independent reviewers evaluated and retrieved information from qualifying papers. Our data consists of five studies with 79,878 patients, 38225 (47.9%) of whom were female. Three studies included 2432 children diagnosed with IBD, and 17 (0.7%) were found with type 1 diabetes (T1D). Two studies comprised 77,446 children diagnosed with T1D and 83 (0.1%) had IBD. Children with immune-mediated diseases are more likely to have IBD, especially Crohn's disease. The included studies found no connection between T1D and childhood IBD. The important but little-known connection between diabetes and IBD in pediatric populations is brought to light by this comprehensive study. We were unable to discover a connection between pediatric IBD and DM. The review does, however, point out significant gaps in the literature, highlighting the need for more studies to comprehend the intricate interactions between these disorders and to create practical management plans for impacted children.
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