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Acute Coronary SyndromeI: Introduction01:30

Acute Coronary SyndromeI: Introduction

3
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
3
Acute Coronary Syndrome II: Pathophysiology and clinical manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and clinical manifestations

3
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
3
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

3
IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
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Acute Coronary Syndrome III: Diagnostic studies01:30

Acute Coronary Syndrome III: Diagnostic studies

3
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Myocarditis I: Introduction01:21

Myocarditis I: Introduction

2
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
2
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

3
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Updated: Jun 9, 2025

Protection of H9c2 Myocardial Cells from Oxidative Stress by Crocetin via PINK1/Parkin Pathway-Mediated Mitophagy
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Takotsubo Syndrome Triggered by Acute Myocardial Infarction.

Pablo González Alirangues1, Verónica Artiaga de la Barrera1, Carlos García Jiménez1

  • 1Cardiology, Hospital Fundación Alcorcón, Alcorcón, ESP.

Cureus
|October 30, 2024
PubMed
Summary

Takotsubo syndrome (TTS) can coexist with coronary artery disease (CAD). Acute coronary syndrome (ACS) may trigger TTS development, challenging previous diagnostic criteria for this reversible heart failure.

Keywords:
apical akinesiamyocardial infarctionstemistress cardiomyopathytakotsubo syndrome

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Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Clinical Medicine

Background:

  • Takotsubo syndrome (TTS) is a reversible heart failure syndrome often mimicking acute myocardial infarction (AMI).
  • Coronary artery disease (CAD) has traditionally been an exclusion criterion for TTS diagnosis.
  • Emerging evidence suggests potential coexistence of TTS and CAD.

Observation:

  • This case series presents findings on the relationship between TTS and CAD.
  • The study observed instances where TTS and CAD occurred simultaneously.
  • Acute coronary syndrome (ACS) was identified as a potential trigger for TTS.

Findings:

  • Takotsubo syndrome (TTS) can indeed coexist with underlying coronary artery disease (CAD).
  • An acute coronary syndrome (ACS) event can precipitate the onset of TTS.
  • This challenges the established view of CAD as a strict exclusion criterion for TTS.

Implications:

  • Revising diagnostic criteria for Takotsubo syndrome may be necessary.
  • Understanding the interplay between ACS and TTS can improve patient management.
  • Further research into the pathophysiology of TTS triggered by ACS is warranted.