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Gilteritinib-Induced Hypopituitarism: A Case Report

Yuri Hori1, Yosuke Okada1, Satomi Sonoda1

  • 1Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, JPN.

Cureus
|October 30, 2024
PubMed

Gilteritinib is a tyrosine kinase inhibitor (TKI) that treats acute myeloid leukemia (AML) by inhibiting FMS-like tyrosine kinase 3 (FLT3). This is a report on hypopituitarism induced by gilteritinib and its resolution following withdrawal. A 54-year-old woman was treated with gilteritinib for AML. She subsequently developed general fatigue. Blood tests showed low levels of anterior pituitary hormone. After 10 months of gilteritinib withdrawal, the levels of anterior pituitary hormones returned to normal values. When nonspecific symptoms such as fatigue in patients treated with gilteritinib are coupled with electrolyte abnormalities, a close checkup for hypopituitarism is recommended.

Keywords:
acute myeloid leukemiadrug withdrawalgilteritinibhypopituitarismpituitary hormone

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