Related Experiment Video
Updated: Aug 7, 2026

12:45
Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
Published on: February 12, 2022
5.6K
Rectal Adenocarcinoma With Pagetoid Spread: A Novel Entity
Lefika Bathobakae1, Pasha Shenasan2, Aakash Trivedi2
1Internal Medicine, St. Joseph's University Medical Center, Paterson, New Jersey, USA.
Case Reports in Gastrointestinal Medicine
|October 30, 2024
Summary
Perianal Paget's disease, a rare adenocarcinoma, can mimic other conditions. This case highlights rectal adenocarcinoma with pagetoid spread, treated with chemoradiation, though definitive surgery was declined due to colostomy implications.
Area of Science:
- Oncology
- Dermatology
- Gastroenterology
Background:
- Perianal Paget's disease (PPD) is a rare adenocarcinoma originating from apocrine glands.
- PPD is frequently misdiagnosed, presenting challenges in timely and accurate diagnosis.
- Differential diagnosis includes various benign and malignant perianal conditions.
Keywords:
Paget's diseasepagetoid spreadperianal Paget's diseaserectal adenocarcinomasecondary Paget's diseasetotal neoadjuvant therapyMore Related Videos
Related Concept Videos
Cancer
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Metastasis
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...

