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Clinical features of Chagas disease progression and severity

Maria Carmo P Nunes1, Caryn Bern2, Eva H Clark3

  • 1Hospital das Clínicas and Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Lancet Regional Health. Americas
|October 30, 2024
PubMed

Insights

Chagas disease causes cardiomyopathy and neurological issues, impacting morbidity and mortality in Latin America. This review details its clinical spectrum, progression factors, and prognostic indicators.

Area of Science:

  • Cardiology
  • Neurology
  • Infectious Diseases

Background:

  • Chagas disease is a leading cause of non-ischemic cardiomyopathy and mortality in Latin America.
  • It presents a wide clinical spectrum, affecting cardiac and neurological functions.
  • Disease progression is influenced by treatment, host-parasite dynamics, and social factors.

Purpose of the Study:

  • To review the clinical presentations of Chagas disease.
  • To explore the spectrum of Chagas cardiomyopathy and neurological manifestations.
  • To analyze factors influencing disease progression and mortality.

Main Methods:

  • Literature review of Chagas disease.
  • Analysis of clinical presentations and prognostic factors.
  • Investigation of treatment, host-parasite interactions, and social determinants.

Main Results:

  • Chagas cardiomyopathy severity, particularly left ventricular dysfunction, dictates prognosis.
  • Neurological effects include cardioembolic strokes and cognitive impairments.
  • Progression is multifactorial, involving anti-parasitic treatment, host-parasite interactions, and social determinants.

Conclusions:

  • Chagas disease presents significant cardiac and neurological morbidity.
  • Understanding prognostic factors is crucial for managing this fatal illness.
  • Further research into influencing factors can improve patient outcomes.

Keywords:
Chagas cardiomyopathyChagas diseaseProgressionSeverity

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