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A Patient with Acute Promyelocytic Leukemia Treated with Isotretinoin: A Case Report
Ilja Goldin1,2, Michael Medinger1,2, Jakob Passweg2
1Division of Internal Medicine, Department of Medicine, University Hospital Basel and University of Basel, Basel, Switzerland.
Introduction:
All-trans retinoic acid (ATRA) in combination with arsenic trioxide (ATO) is standard therapy for low-to-intermediate risk acute promyelocytic leukemia (APL). Isotretinoin, an agent used for acne vulgaris, is similar in its chemical structure and effects to ATRA, and single-case studies report a probable effectiveness in APL.
Case Presentation:
In this case, a patient with newly diagnosed APL was treated with isotretinoin/ATO instead of ATRA/ATO for nearly 4 weeks due to a prescription error and anyway reached a stable complete remission as if treated with ATRA/ATO.
Conclusion:
Treatment of APL with isotretinoin instead of ATRA could possibly be effective.
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