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Differences in cardiovascular outcomes between men and women with acute pancreatitis

Manyun Tang1,2, Yuye Ning3, Jiaqi An4

  • 1Department of Cardiovascular Surgery, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China

Polish Archives of Internal Medicine
|October 30, 2024
PubMed

Insights

Men face higher cardiovascular risks after acute pancreatitis (AP). This study highlights a greater incidence of major cardiovascular and cerebrovascular adverse events (MACCEs) in men, indicating a need for sex-specific care strategies.

Area of Science:

  • Cardiology
  • Gastroenterology
  • Epidemiology

Background:

  • Acute pancreatitis (AP) is linked to increased cardiovascular disease (CVD) risk.
  • Existing research has not clarified if this CVD risk elevation differs between sexes.

Purpose of the Study:

  • To investigate and compare sex-specific differences in long-term cardiovascular outcomes among patients following acute pancreatitis.

Main Methods:

  • Utilized data from the UK Biobank, a large population-based cohort.
  • Defined major cardiovascular and cerebrovascular adverse events (MACCEs) as all-cause death, myocardial infarction, and stroke.
  • Employed Cox regression and win ratio methods for sex difference analysis, adjusting for covariates.

Main Results:

  • 1371 AP patients (42.5% male) were followed for a median of 13.9 years.
  • Men exhibited a higher incidence rate of MACCEs (16.44/1000 person-years) compared to women (9.8/1000 person-years).
  • Men had a significantly higher risk of MACCEs (adjusted HR 1.8), all-cause mortality (adjusted HR 1.49), myocardial infarction (adjusted HR 2.75), and stroke (adjusted HR 1.67).

Conclusions:

  • Men experience more adverse cardiovascular outcomes post-acute pancreatitis compared to women.
  • Findings suggest the necessity for developing and implementing sex-specific management strategies for AP patients to mitigate cardiovascular risks.
Abstract

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