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Evaluation of Post-Processing on Additive Manufactured Bioresorbable Polymers for Medical Devices.

Clayton J Culbreath^1,2, Seth D McCullen^1,2, O Thompson Mefford^2,3

¹Poly-Med, Inc., Anderson, South Carolina 29625, United States.

ACS Applied Bio Materials

|October 30, 2024

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Post-processing techniques like heat treatment and sterilization significantly impact the mechanical properties of additively manufactured resorbable polymer scaffolds for tissue engineering and regenerative medicine (TERM). Careful selection of these parameters is crucial for device development.

Area of Science:

Biomaterials Science
Medical Device Engineering
Polymer Science

Background:

Additive manufacturing (AM) is increasingly used for medical devices, but challenges remain in processing resorbable polymers.
Resorbable polymers are vital for tissue engineering and regenerative medicine (TERM) scaffolds.
Understanding post-processing effects on scaffold properties is critical for clinical translation.

Purpose of the Study:

To evaluate the impact of post-processing parameters on the mechanical properties and in vitro degradation of AM-fabricated resorbable polymer scaffolds.
To investigate the influence of heat treatment and sterilization methods on scaffold morphology and performance.
To establish process-structure-property-performance relationships for biomimetic scaffold design.

Main Methods:

Keywords:

absorbable polymer additive manufacturing degradation sterilization

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Three resorbable polymers (Caproprene 100M, Lactoflex 7415, Lactoprene 100M) were additively manufactured into Type V tensile bars.
Scaffolds underwent various heat treatments to control semicrystalline morphology.
Two sterilization methods were applied: supercritical carbon dioxide and electron beam radiation.
Mechanical properties and in vitro degradation were analyzed using analysis of variance (ANOVA).

Main Results:

Both heat treatment parameters and sterilization methods significantly affected scaffold mechanical properties.
Material type was the primary determinant of mechanical property variation.
Significant interactions were observed between heat treatment, sterilization, and material parameters (alpha = 0.05).
Post-processing demonstrably impacted scaffold structures.

Conclusions:

Post-processing steps, including heat treatment and sterilization, critically influence the performance of AM bioresorbable scaffolds.
These parameters must be considered early in the design process alongside material selection for successful TERM device development.
Optimizing post-processing is essential for achieving desired biomimetic properties and ensuring device efficacy.