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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

390
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Related Experiment Video

Updated: Jun 9, 2025

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
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Engineering CAR-T therapies for autoimmune disease and beyond.

Emily P English1, Rachel N Swingler1, Simran Patwa1

  • 1Cartesian Therapeutics, Gaithersburg, MD 20878, USA.

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Chimeric antigen receptor-T cell (CAR-T) therapy, initially used for blood cancers, is now showing promise for treating autoimmune diseases. This expansion leverages existing CAR-T targets to address new conditions.

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Area of Science:

  • Immunology
  • Cell Therapy
  • Autoimmunity

Background:

  • Chimeric antigen receptor-T cell (CAR-T) therapy has revolutionized hematological malignancy treatment.
  • The success of CAR-T in oncology has prompted exploration beyond cancer applications.
  • Targeting pathogenic cells with engineered T lymphocytes is a validated approach.

Purpose of the Study:

  • To discuss the recent advancements in applying CAR-T technology to autoimmune diseases.
  • To highlight the potential of CAR-T therapy in new therapeutic areas beyond oncology.
  • To review outcomes and pave the way for CAR-T in autoimmunity.

Main Methods:

  • Review of recent scientific literature and clinical outcomes.
  • Analysis of CAR-T technology's adaptation for autoimmune targets.
  • Discussion of validated targets used in both hematology and autoimmunity.

Main Results:

  • Breakthrough progress has been achieved in applying CAR-T technology to autoimmune diseases.
  • CAR-T therapies are now exploiting targets previously validated in hematological cancers.
  • The field is expanding the reach of CAR-T therapy beyond its initial oncological applications.

Conclusions:

  • CAR-T therapy's success in hematological malignancies is paving the way for its use in autoimmune disorders.
  • The established targeting strategies in oncology are being effectively repurposed for autoimmunity.
  • CAR-T technology holds significant potential for treating a broader range of diseases, including autoimmune conditions.