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Census based mortality study of pharmaceutical industry workers.

J M Harrington, P Goldblatt

    British Journal of Industrial Medicine
    |March 1, 1986
    PubMed
    Summary
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    British pharmaceutical workers showed no excess mortality risk. While some minor inconsistencies were observed for suicide and large intestine cancer, the overall findings suggest a healthy workforce, indicating no significant occupational health concerns.

    Area of Science:

    • Occupational Health
    • Epidemiology
    • Pharmaceutical Industry Studies

    Background:

    • Investigating mortality patterns in the British pharmaceutical industry is crucial for understanding occupational health risks.
    • Previous studies may not have sufficiently addressed specific causes of death like cancers and respiratory diseases in this sector.

    Purpose of the Study:

    • To determine if mortality among British pharmaceutical industry workers exhibits occupationally related patterns.
    • To specifically examine associations with cancers and respiratory diseases within different industry sections.

    Main Methods:

    • Utilized census data from 1961 and 1971 for occupational categorization of pharmaceutical workers in England and Wales.
    • Tracked subsequent mortality through the National Health Service Central Registry until the end of 1981.

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  • Calculated Standardized Mortality Ratios (SMRs) and adjusted for the healthy worker effect.

    • Main Results:

    • A "healthy worker effect" was observed, with overall SMRs between 0.77 and 1.04.
    • This effect was reduced by 25% when compared to the general employed population.
    • Inconsistent excesses in mortality were noted for suicide (SMR 0.91-2.79) and large intestine cancer (SMR 1.09-2.38) in small cohorts.

    Conclusions:

    • This census-based study found no clear association between specific pharmaceutical industry sectors and investigated causes of death.
    • Despite methodological limitations, the study indicates no excess mortality risk associated with employment in the pharmaceutical industry.
    • Further research may be needed to explore the observed, though inconsistent, excesses in specific causes of death.