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Related Experiment Videos

Intraocular acyclovir levels after subconjunctival and topical administration.

J Schulman, G A Peyman, R Fiscella

    The British Journal of Ophthalmology
    |February 1, 1986
    PubMed
    Summary
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    Substantial acyclovir levels were found in rabbit eyes after subconjunctival injection. However, topical acyclovir application showed poor penetration into the vitreous, limiting its effectiveness for intraocular infections.

    Area of Science:

    • Ophthalmology
    • Pharmacology
    • Drug Delivery

    Background:

    • Acyclovir is a key antiviral medication used in ophthalmology.
    • Understanding drug penetration into ocular tissues is crucial for effective treatment.

    Purpose of the Study:

    • To quantify acyclovir levels in ocular tissues after subconjunctival injection.
    • To evaluate the intravitreal penetration of topical acyclovir.

    Main Methods:

    • Subconjunctival injection of acyclovir in New Zealand rabbits.
    • Measurement of acyclovir concentrations in aqueous and vitreous humor over time.
    • Assessment of topical acyclovir efficacy on intraocular penetration.

    Main Results:

    • Significant acyclovir concentrations were detected in both aqueous and vitreous humor post-injection.

    Related Experiment Videos

  • Topical acyclovir application demonstrated limited penetration into the vitreous humor.

    • Conclusions:

    • Subconjunctival injection is an effective route for achieving therapeutic acyclovir levels in the anterior and posterior segments of the eye.
    • Topical acyclovir has poor intravitreal penetration, suggesting it may not be optimal for treating posterior segment ocular viral infections.