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Updated: Jun 9, 2025

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
The interplay of gut microbiota, obesity, and depression: insights and interventions
Iryna Halabitska1, Pavlo Petakh2, Iryna Kamyshna3
1Department of Therapy and Family Medicine, I. Horbachevsky Ternopil National Medical University, Voli Square, 1, Ternopil, 46001, Ukraine.
Abstract:
The gut microbiome, body weight, and related comorbidities are intricately linked through a complex interaction of microbial, genetic, environmental, and psychological factors. Alterations in gut microbiota can contribute to the development of weight disorders and depressive symptoms, with the potential for these relationships to be bidirectional. Effective management of these interconnected conditions often involves a combination of lifestyle modifications and psychological support. Medical interventions, including treatments for obesity, antidiabetic drugs, antidepressants, antibiotics, and probiotics, can have beneficial and detrimental effects on gut microbiota and mental health. Further research is needed to better understand their impact on gut microbiome and mental health in the context of obesity.
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