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Prognostic Significance Of Cd3+ And Cd8+ T-cells Immunoscore In Renal Cell Carcinoma: A Comparison Between Two Simple Models For Assessment.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Prognostic Significance Of Cd3+ And Cd8+ T-cells Immunoscore In Renal Cell Carcinoma: A Comparison Between Two Simple Models For Assessment.

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Prognostic significance of CD3+ and CD8+ T-cells immunoscore in renal cell carcinoma: A comparison between two simple models for assessment.

Amira Emad Elwy¹, Mahmoud Ismail Nassar², Shimaa Hassan Shaban¹

¹Department of Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Annals of Diagnostic Pathology

|October 30, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

The immunoscore (ISc) indicates worse survival in renal cell carcinoma (RCC) patients. High ISc predicts recurrence, aiding personalized treatment strategies and improving prognostic accuracy.

Keywords:

CD3 +CD8+Immunoscore Prognosis

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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

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Published on: April 12, 2017

Area of Science:

Oncology
Immunology
Pathology

Background:

The immunoscore (ISc) is a prognostic indicator in various solid tumors.
Its role in renal cell carcinoma (RCC) requires further investigation.
This study evaluates the prognostic value of ISc using CD3+ and CD8+ T cells in RCC.

Purpose of the Study:

To ascertain the prognostic value of the immunoscore (ISc) in non-metastatic renal cell carcinoma (RCC) patients.
To analyze the association between ISc and clinicopathological factors, including survival.
To explore a modified quantification method for immune cells to improve clinical utility.

Main Methods:

115 non-metastatic RCC patients undergoing nephrectomy were included.
ISc was determined by quantifying CD3+ and CD8+ T cells (cell count/mm² and % of cells/mm²) at tumor margins and center.

Renal cell carcinoma

Statistical analyses correlated ISc with clinicopathological characteristics and survival outcomes.

Main Results:

High ISc was significantly associated with adverse clinicopathological factors.
Patients with high ISc exhibited significantly worse overall survival (OS) and disease-free survival (DFS) (p < 0.001).
High ISc predicted shortened DFS in univariate analysis but was a dependent predictor in multivariate analysis.

Conclusions:

High ISc is a potential predictor of recurrence in RCC patients.
ISc may guide personalized treatment strategies for improved patient care.
A modified, automated quantification method (% of cells/mm²) offers a simpler, more efficient, and clinically meaningful approach for routine ISc assessment.