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Author Spotlight: THP-1 Macrophage Response to LPS/ATP — Unveiling the Pyroptosis, Apoptosis, and Necroptosis Spectrum
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The regulation of pyroptosis by post-translational modifications: molecular mechanisms and therapeutic targets

Yi-Rao Zhou1, Jun-Jie Dang1, Qi-Chao Yang1

  • 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Frontier Science Centre for Immunology and Metabolism, Taikang Center for Life and Medical Sciences, Wuhan University, Wuhan, 430079, China.

Ebiomedicine
|October 30, 2024
PubMed

Insights

Pyroptosis, a programmed cell death process, is regulated by post-translational modifications (PTMs). Understanding PTMs offers new therapeutic strategies for cancer and inflammatory diseases.

Area of Science:

  • Cellular biology
  • Immunology
  • Biochemistry

Background:

  • Pyroptosis is a programmed cell death pathway involving gasdermin proteins.
  • It releases immune-stimulating substances, crucial for anti-tumor and anti-pathogen responses.
  • Pyroptosis pathways involve caspases and gasdermin cleavage.

Purpose of the Study:

  • To comprehensively review the influence of post-translational modifications (PTMs) on pyroptosis.
  • To identify PTMs, their modifying enzymes, and their specific roles in pyroptosis.
  • To explore therapeutic applications of PTM regulation in diseases.

Main Methods:

  • Literature review of studies on PTMs and pyroptosis.
  • Analysis of PTMs' effects on protein properties and pyroptosis regulation.
  • Examination of therapeutic potential of PTM modulation.

Main Results:

  • Various PTMs significantly impact pyroptosis activity, stability, and function.
  • Specific PTMs and their enzymes are identified as key regulators.
  • PTMs offer potential targets for treating cancer and inflammatory conditions.

Conclusions:

  • Post-translational modifications are critical regulators of pyroptosis.
  • Targeting PTMs in pyroptosis presents promising therapeutic avenues for diseases.
  • Further research into PTMs can advance pyroptosis-based therapies.
Keywords:
Cancer immunotherapyInflammationPost-translational modificationPyroptosisTumour

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