Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Non-Infectious Choroiditis Subdivided into Its Diverse Pathophysiological Sub-Groups Is the Best-Known and Most Appropriate Nomenclature to Date for the Reclassification and Diagnosis of Former White Dot Entities.

Diagnostics (Basel, Switzerland)·2026

Same author

A Report of Lumbar Disk Herniation Treatment Outcomes: Percutaneous Laser Disk Decompression vs Open Microdiscectomy.

Basic and clinical neuroscience·2026

Same author

Sorghum Starch and Protein Digestibility: Mechanisms, Modifications, and Health Implications.

Foods (Basel, Switzerland)·2026

Same author

Retinal microvasculature changes in long-term consumption of hydroxychloroquine.

Scientific reports·2026

Same author

The national neuromyelitis optica spectrum disorders registry system of Iran (NMORI): Aspects and methodological dimensions.

Multiple sclerosis and related disorders·2026

Same author

Quantitative imaging for assessing uveitis activity: A comprehensive review.

Survey of ophthalmology·2026

Same journal

Bridging to low-dose corticosteroids after satralizumab discontinuation in unplanned pregnancy: Two cases of AQP4-positive NMOSD.

Multiple sclerosis and related disorders·2026

Same journal

Does laughter yoga really improve fatigue, sleep quality and psychological wellbeing in people living with MS?

Multiple sclerosis and related disorders·2026

Same journal

The many faces of the multiple sclerosis population in Canada.

Multiple sclerosis and related disorders·2026

Same journal

Patterns of psychological resilience and social avoidance among the patients of Neuromyelitis Optica Spectrum Disease: a latent profile analysis.

Multiple sclerosis and related disorders·2026

Same journal

Discontinuation of disease-modifying therapies in patients with multiple sclerosis: A retrospective case-control study.

Multiple sclerosis and related disorders·2026

Same journal

Real-world analytical and clinical evaluation of the Siemens Atellica® immunoassay for plasma neurofilament light chain in multiple sclerosis.

Multiple sclerosis and related disorders·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 5, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

Multiple sclerosis-associated uveitis in Persian population, a multicenter study.

Pasha Anvari¹, Sahba Fekri², Alireza Hedayatfar³

¹Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Multiple Sclerosis and Related Disorders

|October 30, 2024

Summary

This summary is machine-generated.

Multiple sclerosis-associated uveitis (MSU) in Persians often presents as chronic, bilateral intermediate uveitis in females, sometimes mimicking undifferentiated intermediate uveitis. Early neuroimaging is recommended in high MS prevalence areas for suspected cases.

Keywords:

Demyelinating plaque associated uveitis Granulomatous keratic precipitate Multiple sclerosis associated uveitis Neuroimaging Retinal vasculitis Undifferentiated Intermediate uveitis

More Related Videos

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

Related Experiment Videos

Last Updated: May 5, 2026

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Experimental Autoimmune Uveitis: An Intraocular Inflammatory Mouse Model

Published on: January 12, 2022

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Primed Mycobacterial Uveitis PMU as a Model for Post-Infectious Uveitis

Published on: December 17, 2021

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

Area of Science:

Ophthalmology
Neurology
Immunology

Background:

Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
Uveitis, inflammation of the vascular layer of the eye, can be associated with MS.
Understanding the characteristics of MS-associated uveitis (MSU) is crucial for timely diagnosis and management.

Purpose of the Study:

To characterize multiple sclerosis-associated uveitis (MSU) in the Persian population.
To identify epidemiological, clinical, and visual outcome patterns of MSU.

Main Methods:

Retrospective, nonrandomized, multicenter study.
Analysis of epidemiological data, ocular and neurological findings, angiographic features, and visual outcomes in 92 patients with MSU.
Review of fluorescein angiography (FA) findings and causes of visual impairment.

Main Results:

MSU predominantly affected females (84.8%) with a mean age of 35.9 years, often presenting as bilateral intermediate uveitis (84.8%) with a chronic, granulomatous course (81.9%).
MS diagnosis preceded uveitis in 48.8% of cases (median 7 years prior) and followed in 52.2% (median 2 years later).
Peripheral retinal perivascular leakage (81.4%) and optic disc hyperfluorescence (74.4%) were common FA findings; cataracts (52.7%) and cystoid macular edema (31.5%) were major causes of visual impairment.

Conclusions:

MSU typically manifests as chronic, bilateral, granulomatous intermediate uveitis, particularly in females, and can present as isolated anterior uveitis or retinal vasculitis.
Clinically, MSU may resemble undifferentiated intermediate uveitis, highlighting the need for neuroimaging in endemic areas.
Expanded neuroimaging indications for chronic granulomatous uveitis, especially with retinal vasculitis, are suggested in regions with high MS prevalence.