Related Experiment Video

Updated: Jun 9, 2025

Total Protein Extraction and 2-D Gel Electrophoresis Methods for Burkholderia Species
08:31

Total Protein Extraction and 2-D Gel Electrophoresis Methods for Burkholderia Species

Published on: October 15, 2013

29.9K

A rare case of infectious aortitis caused by Burkholderia pseudomallei

James Dodd1, Bibombe Mwipatayi2, Amber Louw3

  • 1Department of Vascular Surgery, Royal Perth Hospital, Perth, Australia.

International Journal of Surgery Case Reports
|October 30, 2024
PubMed
Abstract

Insights

Melioidosis, a severe infection caused by Burkholderia pseudomallei, can affect the aorta. A rare case of melioidotic penetrating aortic ulcer was successfully treated with a neoaortoiliac system, demonstrating effective management of complex vascular infections.

Area of Science:

  • Infectious Diseases
  • Vascular Surgery
  • Cardiology

Background:

  • Melioidosis, caused by Burkholderia pseudomallei, typically affects non-vascular organs.
  • Vascular involvement in melioidosis, such as mycotic aneurysms, carries a high mortality rate.
  • Early recognition and intervention are crucial for managing severe melioidosis infections.

Observation:

  • A 70-year-old male with diabetes and ischemic heart disease presented with acute abdominal and back pain.
  • An infrarenal penetrating aortic ulcer (PAU) was identified without aneurysmal changes.
  • Blood cultures revealed Burkholderia pseudomallei, diagnosing melioidosis-associated aortitis post-emergency endovascular aortic repair (EVAR).

Findings:

  • The patient underwent a complex single-stage neoaortoiliac system procedure for aortic reconstruction.
  • Despite complications including wound infection and sepsis, the patient achieved functional independence 15 months post-surgery.
  • Successful management of this rare melioidotic aortic infection was achieved through a multidisciplinary approach.

Implications:

  • This case highlights the importance of considering melioidosis in infectious aortitis, especially with a travel history to endemic areas.
  • Effective management of melioidotic aortic infections requires timely diagnosis and often emergency surgical intervention.
  • The neoaortoiliac system procedure proved effective for definitive treatment in this challenging vascular infection case.
Keywords:
Burkholderia pseudomalleiCase reportInfective aortitisMelioidosisPenetrating aortic ulcer

More Related Videos

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis07:27

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis

Published on: February 24, 2023

3.1K
Essential Components of Borreliella Borrelia burgdorferi In Vitro Transcription Assays07:15

Essential Components of Borreliella Borrelia burgdorferi In Vitro Transcription Assays

Published on: July 22, 2022

1.2K

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
2
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
2
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
212
Endocarditis II: Clinical features and Diagnostic Tests01:25

Endocarditis II: Clinical features and Diagnostic Tests

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
2
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
305