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Related Concept Videos

Electrical Synapses01:28

Electrical Synapses

Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...

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Flexible and Extensible Ribbon-Cable Interconnects for Implantable Electrical Neural Interfaces.

Negar Geramifard1, Mahasty Khajehzadeh1, Behnoush Dousti1

  • 1Department of Bioengineering, The University of Texas at Dallas, Richardson, Texas 75080, United States.

ACS Applied Materials & Interfaces
|October 30, 2024
PubMed
Summary
This summary is machine-generated.

Researchers developed highly flexible and extensible thin-film ribbon cables for neural implants. A novel lattice design enables up to 300% elongation, improving integration with microelectrode arrays for better neural recording.

Keywords:
amorphous silicon carbideelectrical interconnectsflexible electronicsneural recordingribbon cables

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Neuroscience

Background:

  • Implanted neural devices require reliable electrical interconnects.
  • Existing interconnects often lack the flexibility and extensibility needed for optimal integration with microelectrode arrays.
  • Thin-film technologies offer potential for miniaturized and flexible neural interfaces.

Purpose of the Study:

  • To design and characterize novel thin-film ribbon cables for neural stimulation and recording devices.
  • To develop flexible and extensible interconnects that integrate seamlessly with thin-film microelectrode arrays (MEAs).
  • To investigate a lattice geometry for enhanced cable extensibility without compromising electrical function.

Main Methods:

  • Fabrication of multichannel ribbon cables using amorphous silicon carbide (a-SiC), polyimide, and titanium/gold thin films.
  • Investigation of linear, serpentine, and open lattice electrical trace designs via photolithography and thin-film processing.
  • Characterization of cable flexibility, tensile elongation tolerance, and impedance changes.
  • Development and testing of an electrical interconnect process using conductive epoxy for MEA integration.
  • In vivo testing of the ribbon cable-MEA system for acute neuronal recording in rat cortex.

Main Results:

  • Ribbon cables demonstrated tolerance to flexural bending (50 μm radius) without impedance change.
  • Standard designs failed at <5% tensile elongation, while lattice designs achieved 300% elongation without failure.
  • Lattice structure's out-of-plane displacement mechanism prevents fracture during high elongation.
  • Extensible cables withstood 50,000 cycles of 45% tensile extension without failure.
  • Successful acute neuronal recording was achieved using the ribbon cable connected to an a-SiC MEA in rat cortex.

Conclusions:

  • Highly flexible and extensible thin-film ribbon cables were successfully designed and fabricated.
  • The lattice geometry is crucial for achieving significant elongation tolerance in neural interconnects.
  • These cables can accommodate large extensions, aiding surgical implantation and potentially reducing tethering forces on MEAs.
  • The developed interconnects show promise for improving chronic neural recording performance and device longevity.