Comprehensive review on leucine-rich pentatricopeptide repeat-containing protein (LRPPRC, PPR protein): A burgeoning target for cancer therapy

Yunxiao Ge ¹, Victor Janson ², Hui Liu ³

⁰Department of Pathophysiology, School of Basic Medical Sciences, College of Medicine, Zhengzhou University, Zhengzhou, Henan 450001, China; China-US (Henan) Hormel Cancer Institute, No.127, Dongming Road, Jinshui District, Zhengzhou, Henan 450008, China.

International Journal of Biological Macromolecules +

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October 30, 2024

View abstract on PubMed

Summary

Leucine-rich pentatricopeptide repeat-containing (LRPPRC) protein is crucial in cell functions and its elevated expression is linked to poor cancer prognosis. Targeting LRPPRC shows promise for cancer therapy and as a biomarker.

Area Of Science

Molecular Biology
Genetics
Cancer Research

Background

Leucine-rich pentatricopeptide repeat-containing (LRPPRC) protein is encoded by the LRPPRC gene, implicated in Leigh Syndrome French Canadian.
LRPPRC regulates gene transcription and translation by interacting with DNA, RNA, and proteins, influencing cell fate.
Emerging evidence highlights LRPPRC's significant role in human diseases, especially in recent cancer research.

Purpose Of The Study

To review the structure, function, molecular mechanisms, and inhibitors of LRPPRC.
To consolidate current understanding of LRPPRC's involvement in cancer.
To evaluate LRPPRC as a potential therapeutic target and biomarker in oncology.

Main Methods

Literature review focusing on LRPPRC's role in cellular processes and disease.
Analysis of LRPPRC expression patterns in various cancer types.
Examination of LRPPRC's impact on cancer hallmarks like signal transduction, metabolism, and immune regulation.

Main Results

LRPPRC expression is elevated in most cancer types.
High LRPPRC expression correlates with poor prognosis in cancer patients.
Targeting LRPPRC effectively suppresses tumor progression by modulating key cancer pathways.

Conclusions

LRPPRC is a promising therapeutic target and biomarker in cancer research.
Modulating LRPPRC function can impact cancer hallmarks, including metabolism and immune response.
Further research is needed to fully elucidate LRPPRC's mechanisms and optimize therapeutic strategies.

Keywords:

Cancer metabolism Cancer therapy Immune regulation LRPPRC Signal transduction