Related Experiment Video

Updated: Jun 20, 2026

Mobile Game-based Virtual Reality Program for Upper Extremity Stroke Rehabilitation
05:52

Mobile Game-based Virtual Reality Program for Upper Extremity Stroke Rehabilitation

Published on: March 8, 2018

18.8K

Randomized Comparison Trial of Rehabilitation Very Early for Infants with Congenital Hemiplegia

Roslyn N Boyd1, Susan Greaves2, Jenny Ziviani3

  • 1Queensland Cerebral Palsy and Rehabilitation Research Centre, The University of Queensland, Queensland, Australia.

The Journal of Pediatrics
|October 30, 2024
PubMed

Insights

Constraint-induced movement therapy (Baby-CIMT) and bimanual therapy (Baby-BIM) similarly improved hand function in infants at high risk for unilateral cerebral palsy. Early intervention before 6 months showed greater hand function gains.

Area of Science:

  • Pediatric Rehabilitation
  • Neurology
  • Developmental Pediatrics

Background:

  • Infants at high risk for unilateral cerebral palsy often exhibit asymmetrical hand use.
  • Early intervention is crucial for optimizing motor development and functional outcomes.

Purpose of the Study:

  • To compare the efficacy of constraint-induced movement therapy (Baby-CIMT) versus bimanual therapy (Baby-BIM) in infants at high risk for unilateral cerebral palsy.
  • To evaluate the impact of early intervention on hand function and developmental outcomes.

Main Methods:

  • A single-blind, randomized-controlled trial involving 96 infants (3-9 months corrected age) with asymmetric brain lesions and absent fidgety General Movements.
  • Infants were randomized to receive either Baby-CIMT or Baby-BIM home-based intervention for 6-9 months.
  • Primary outcome was the Hand Assessment for Infants (HAI) score post-intervention; secondary outcomes included Mini-Assisting Hand Assessment and Bayley III cognition at 24 months corrected age.

Main Results:

  • No significant difference in HAI scores between Baby-CIMT and Baby-BIM immediately post-intervention.
  • Both interventions led to clinically significant improvements in hand function from baseline.
  • Infants starting intervention before 6 months corrected age demonstrated greater improvements in hand function compared to those starting later.

Conclusions:

  • Baby-CIMT is not superior to Baby-BIM for infants at high risk of unilateral cerebral palsy.
  • Both therapies effectively improve hand development in this population.
  • Early intervention (before 6 months corrected age) is associated with superior hand function outcomes.
Abstract

More Related Videos

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy07:20

Author Spotlight: Repetitive Transcranial Magnetic Stimulation Combined with Movement Observation in Cerebral Palsy

Published on: August 9, 2024

1.1K
Author Spotlight: Enhancing Upper Limb Rehabilitation in Stroke Patients Through Advanced Robotic and Neuromodulation Technologies05:28

Author Spotlight: Enhancing Upper Limb Rehabilitation in Stroke Patients Through Advanced Robotic and Neuromodulation Technologies

Published on: October 11, 2024

499

Related Concept Videos

Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...
Development of Immunocompetence01:22

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...
Language Development01:22

Language Development

Children master language quickly and with relative ease, supported by both biological predisposition and reinforcement. B. F. Skinner (1957) proposed that language is learned through reinforcement, while Noam Chomsky (1965) argued that language acquisition mechanisms are biologically determined.
The critical period for language acquisition suggests that the ability to acquire language is at its peak early in life. As people age, this proficiency decreases. Language development begins very...