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Central error-correcting behavior in schizophrenia and depression.

R C Malenka, R W Angel, S Thiemann

    Biological Psychiatry
    |March 1, 1986
    PubMed
    Summary
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    Schizophrenia patients show a significant deficit in correcting movement errors using internal cues. This impairment in self-monitoring appears specific to schizophrenia, unlike in depression.

    Area of Science:

    • Neuroscience
    • Psychiatry
    • Cognitive Psychology

    Background:

    • Previous research indicated motor control deficits in schizophrenia without external feedback.
    • The specificity of this impairment across psychiatric disorders remained unclear.

    Purpose of the Study:

    • To investigate the specificity of motor error correction deficits in schizophrenia.
    • To compare schizophrenic subjects with depressed and normal subjects on an internal cue-based motor task.

    Main Methods:

    • A tracking task was employed, minimizing exteroceptive (external) cues for error correction.
    • Schizophrenic (n=9), depressed (n=11), and normal (n=8) subjects participated.

    Main Results:

    • Schizophrenic subjects exhibited significant impairment in error correction.

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  • No significant differences were found between depressed and normal subjects.
  • Schizophrenia subjects showed no deficit in initiating correct movements.

    • Conclusions:

    • The inability to use internal, self-generated cues for motor behavior monitoring is likely specific to schizophrenia.
    • This suggests a core deficit in self-monitoring within schizophrenia spectrum disorders.