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Effect of naltrexone on mood and cognitive functioning among overweight men
Biological Psychiatry
|March 1, 1986
Summary
High-dose naltrexone (300 mg/day) did not significantly impact mood or cognitive functions in overweight adult men over an 8-week period. This study found no significant effects of naltrexone on mood or cognition.
Area of Science:
- Pharmacology
- Neuroscience
- Obesity Research
Background:
- Naltrexone is an opioid antagonist used in addiction treatment.
- Overweight individuals may experience mood and cognitive alterations.
- The impact of naltrexone on mood and cognition in this population is not well-established.
Purpose of the Study:
- To investigate the effects of naltrexone on mood and cognitive performance.
- To assess the efficacy of high-dose naltrexone in overweight adult males.
Main Methods:
- Double-blind, placebo-controlled study design.
- Randomized prescription of naltrexone (300 mg/day) or placebo for 8 weeks.
- Inclusion of overweight adult male subjects.
Main Results:
- Chronic administration of high-dose naltrexone (300 mg/day) showed no significant changes in mood.
- Cognitive functioning remained unaffected by naltrexone treatment.
- No statistically significant differences were observed between the naltrexone and placebo groups.
Conclusions:
- High-dose naltrexone (300 mg/day) does not appear to alter mood or cognitive functions in overweight adult men.
- Further research may be needed to explore potential effects in different populations or dosages.