Is There a Correlation Between Platelet Count, Mesenteric Lymph Node Involvement, and Hematogenous Metastases in...

Area of Science:

• Oncology
• Gynecologic Oncology
• Cancer Biomarkers

Background:

• Ovarian cancer is a leading cause of cancer death in women globally.
• Late diagnosis and lack of effective screening hinder early detection.
• Identifying prognostic factors is crucial for managing advanced disease.

Purpose of the Study:

• To investigate the prognostic significance of preoperative platelet count in advanced ovarian cancer.
• To determine the association between thrombocytosis and disease characteristics.
• To evaluate the impact of platelet count on long-term patient outcomes.

Main Methods:

• Retrospective review of 57 patients undergoing cytoreductive surgery (2014-2019).
• Classification based on preoperative platelet count (cut-off: 335,000/μl).
• Analysis of correlations between platelet count, disease indices, and survival.

Main Results:

• Patients with higher preoperative platelet counts (>335,000/μl) showed significantly increased peritoneal carcinomatosis.
• Elevated platelet counts correlated with greater digestive serosa and mesenteric lymph node involvement.
• Thrombocytosis was associated with a higher incidence of hematogenous metastases and impacted overall survival.

Conclusions:

• Preoperative thrombocytosis is a significant prognostic factor in advanced ovarian cancer.
• It correlates with indicators of more aggressive disease, including metastasis.
• Platelet count may aid in predicting long-term outcomes for ovarian cancer patients.