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Author Spotlight: Enhancing Candida albicans Detection in Catheter Infections Using Fluorescent Protein Tagging
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Factors Associated With Mortality in Patients With Catheter-related Bloodstream Infection: A Multicenter
Akihiko Futamura1, Takenao Koseki2, Tsuyoshi Nakai2
1Department of Pharmacy, Fujita Health University Nanakuri Memorial Hospital, Tsu, Japan; futamura@fujita-hu.ac.jp.
In Vivo (Athens, Greece)
|October 30, 2024
Summary
Catheter-related bloodstream infections (CRBSI) pose a significant mortality risk. Key factors include Candida, early onset, concurrent infections, low albumin, and high CRP, while peripherally inserted central catheters may reduce risk.
Area of Science:
- Infectious Diseases
- Critical Care Medicine
- Clinical Nutrition
Background:
- Catheter-related bloodstream infections (CRBSI) are serious complications with unclear mortality predictors.
- Nutritional status is rarely studied in relation to CRBSI mortality.
Purpose of the Study:
- To identify factors associated with mortality in patients diagnosed with CRBSI.
- To specifically investigate the role of nutritional factors in CRBSI mortality.
Main Methods:
- Retrospective, multicenter study involving 453 patients with CRBSI across 33 hospitals.
- Unadjusted and multivariable logistic regression analyses were used to determine mortality risk factors.
Main Results:
- Mortality was associated with Candida bloodstream detection, CRBSI onset within 30 days of catheterization, and concurrent infections.
- Low serum albumin and elevated C-reactive protein (CRP) levels were identified as risk factors for mortality.
- Use of a peripherally inserted central catheter (PICC) was linked to a reduced risk of CRBSI mortality.
Conclusions:
- Factors like Candida, early CRBSI onset, concurrent infections, low serum albumin, and high CRP predict mortality.
- Monitoring these factors and considering PICC use can help mitigate CRBSI severity and reduce death risk.
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