Two Stage Sinus Lifting Using Nanohydroxyapatite Particles Versus Deproteinized Bovine Bone: Randomized Clinical...

Area of Science:

• Oral and Maxillofacial Surgery
• Regenerative Medicine
• Biomaterials Science

Background:

• Sinus floor elevation is a key procedure for augmenting vertically deficient maxillary alveolar ridges.
• Xenografts and hydroxyapatite are established biomaterials for sinus augmentation.
• Comparing novel biomaterials like nanohydroxyapatite with traditional ones is crucial for advancing augmentation techniques.

Purpose of the Study:

• To compare the bone quality and quantity generated by nanohydroxyapatite (NHA) versus deproteinized bovine bone (DBB) in sinus augmentation procedures.
• To evaluate the efficacy of NHA as a bone graft substitute in comparison to a widely used xenograft.

Main Methods:

• A randomized controlled trial involving 24 patients undergoing sinus floor elevation.
• Augmentation was performed using either NHA or DBB (control group).
• Bone height was measured preoperatively, immediately postoperatively, and at 6 months; histological and histomorphometric analyses assessed bone quality.

Main Results:

• Both NHA and DBB groups showed good bone consolidation with no significant difference in mean bone height at 6 months (11.72 mm vs 12.01 mm).
• Histomorphometric analysis revealed no significant differences in newly formed bone percentage (29.84% vs 34.73%) or residual graft material (32.43% vs 30.43%) between NHA and DBB groups.
• Histological evaluation showed no significant differences in bone regeneration parameters between the two groups.

Conclusions:

• Nanohydroxyapatite (NHA) and deproteinized bovine bone (DBB) yield comparable results in terms of regenerated bone quality and quantity following sinus floor augmentation.
• Further research with larger sample sizes and longer follow-up periods is recommended to solidify these findings.