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Neural repair function of osteopontin in stroke and stroke‑related diseases (Review)
1Department of Neurosurgery, Yanbian University Affiliated Hospital, Yanbian University, Yanji, Jilin 133000, P.R. China.
Insights
Osteopontin (OPN) plays a role in neural repair after stroke. This review explores OPN
Area of Science:
- Neuroscience
- Biochemistry
Background:
- Stroke, a leading cause of death and disability, involves central nervous system damage.
- While treatments have improved survival, nerve function repair post-stroke is a critical research focus.
- Osteopontin (OPN), an extracellular matrix protein, has diverse roles in pathophysiological processes.
Purpose of the Study:
- To comprehensively analyze Osteopontin's specific role in neural repair.
- To explore the relationship between Osteopontin and stroke, including atherosis and neuroplasticity.
Main Methods:
- Literature search of PubMed, Web of Science, and Cochrane databases for Osteopontin and stroke-related articles.
- Summarization of existing research on Osteopontin's structure, isoforms, and functions.
- Exploration of Osteopontin's neural repair mechanisms and association with stroke.
Main Results:
- Osteopontin exhibits varied functions through its fragmented forms.
- OPN is implicated in various diseases, including tumors, inflammation, and autoimmune disorders.
- OPN is a potential diagnostic and therapeutic marker.
Conclusions:
- Osteopontin is involved in the neural repair process following stroke.
- Understanding Osteopontin's mechanisms can inform future stroke treatments and therapies.
- Further research into Osteopontin's role in stroke and related diseases is warranted.
Abstract:
Stroke, including hemorrhagic stroke and ischemic stroke, is a common disease of the central nervous system. It is characterized by a high mortality and disability rate and is closely associated with atherosclerosis, hypertension hyperglycemia, atrial fibrillation and unhealthy living habits. The continuous development of surgery and medications has decreased the mortality rate of patients with stroke and has greatly improved the disease prognosis. At present, the direction of clinical treatment and research has gradually shifted to the repair of nerve function after stroke. Osteopontin (OPN) is a widely distributed extracellular matrix protein. Due to its structural characteristics, OPN can be cut and modified into terminal fragments with different functions, which play different roles in various pathophysiological processes, such as formation of tumors, inflammation and autoimmune diseases. It has also become a potential diagnostic and therapeutic marker. In order to comprehensively analyze the specific role of OPN in nerve repair and its relationship with stroke and stroke-related diseases, the following key words were used: 'Osteopontin, stroke, atherosis, neuroplasticity, neural repair'. PubMed, Web of Science and Cochrane articles related to OPN were searched and summarized. The present review describes the OPN structure, isoforms, functions and its neural repair mechanism, and its association with the occurrence and development of stroke and related diseases was explored.
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