Adenosine A2a Receptor Polymorphisms and Susceptibility to Anxiety Disorders
Mohammad Keyvanloo Shahrestanaki1, Haniyeh Karami1, Hadi Lotfi2
1Department of Biochemistry and Nutrition, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Iranian Journal of Child Neurology
|October 31, 2024
Summary
Genetic variations in the adenosine A2a receptor (ADORA2A) gene are linked to anxiety disorders (ADs). Specific ADORA2A polymorphisms, like rs5751876 and rs35060421, increase susceptibility to ADs.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Anxiety disorders (ADs) involve abnormal signaling of the adenosine A2a receptor (ADORA2A).
- Previous studies on ADORA2A gene polymorphisms and ADs susceptibility have yielded inconsistent results.
Purpose of the Study:
- To systematically review and clarify the association between ADORA2A gene polymorphisms and susceptibility to anxiety disorders.
Main Methods:
- A systematic review of studies was conducted using PubMed/Medline, Web of Science, and Scopus databases.
- Studies were screened based on predefined inclusion/exclusion criteria to identify relevant research.
Main Results:
- The ADORA2A polymorphisms rs5751876 and rs35060421 were associated with increased susceptibility to anxiety disorders.
- The rs2298383 TT genotype may be a causal regulatory factor, and ADORA2A T/C haplotypes (rs2298383/rs3761422) showed significant susceptibility to ADs development.
Conclusions:
- Specific ADORA2A gene polymorphisms are associated with anxiety disorder susceptibility.
- Further research is required to fully elucidate the role of ADORA2A gene polymorphisms in the pathogenesis of anxiety disorders.
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