Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lifespan normative modeling of brain microstructure.

Nature communications·2026
Same author

Convergence and divergence of molecular phenotypes in iPSC-derived models of 16p11.2 and 22q11.2 reciprocal copy number variants.

Current opinion in genetics & development·2026
Same author

Contributions of regional cortical thickness and surface area to cognitive functioning in psychosis-risk.

Schizophrenia research·2026
Same author

Theta Oscillations Assessed From a Passive Auditory Oddball Paradigm in Individuals at Clinical High-Risk for Psychosis and Healthy Control Individuals: Associations with Clinical Outcomes and Mismatch Negativity.

Biological psychiatry global open science·2026
Same author

In memoriam - Robert M. Bilder, Ph.D.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2026
Same author

Multicenter retrospective study on effectiveness, reported side effects, and cognitive outcomes of SSRIs in 22q11.2 deletion syndrome.

Research square·2026
Same journal

Tiny Lungs, Big Challenges: Pediatric and Premature Lung Segmentation using Deep Learning.

... International Symposium on Medical Information Processing and Analysis. International SIPAIM Workshop·2025
Same journal

Personalized phenotype encoding and prediction of pathological head development from cross-sectional images.

... International Symposium on Medical Information Processing and Analysis. International SIPAIM Workshop·2025
See all related articles

Related Experiment Video

Updated: Jun 9, 2025

Three-Dimensional Shape Modeling and Analysis of Brain Structures
05:33

Three-Dimensional Shape Modeling and Analysis of Brain Structures

Published on: November 14, 2019

7.0K

Large-scale Normative Modeling of Brain Microstructure.

Julio E Villalón-Reina1, Alyssa H Zhu1, Talia M Nir1

  • 1Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

... International Symposium on Medical Information Processing and Analysis. International SIPAIM Workshop
|October 31, 2024
PubMed
Summary
This summary is machine-generated.

This study created the first large-scale brain white matter model using diffusion MRI from over 50,000 individuals. This normative model helps identify brain abnormalities in various neurological and psychiatric conditions.

Keywords:
diffusion tensor imaginghierarchical Bayesian regressionnormative modelingwhite matter microstructure

More Related Videos

Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

998
3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

7.2K

Related Experiment Videos

Last Updated: Jun 9, 2025

Three-Dimensional Shape Modeling and Analysis of Brain Structures
05:33

Three-Dimensional Shape Modeling and Analysis of Brain Structures

Published on: November 14, 2019

7.0K
Modeling the Functional Network for Spatial Navigation in the Human Brain
05:55

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

998
3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol
10:14

3D Scanning Technology Bridging Microcircuits and Macroscale Brain Images in 3D Novel Embedding Overlapping Protocol

Published on: May 12, 2019

7.2K

Area of Science:

  • Neuroimaging
  • Computational Neuroscience
  • Biostatistics

Background:

  • Normative models of brain metrics are crucial for identifying abnormalities in neurological, psychiatric, and developmental conditions.
  • Existing methods for harmonizing multi-site neuroimaging data have limitations.

Purpose of the Study:

  • To develop the first large-scale normative model of white matter (WM) microstructure across the lifespan.
  • To establish a standardized reference for detecting and visualizing WM deviations in various patient cohorts.
  • To compare disease effects and identify factors influencing brain abnormalities.

Main Methods:

  • Utilized 18 international diffusion MRI (dMRI) datasets (N=51,830, age 3-80 years).
  • Extracted regional diffusion tensor imaging (DTI) metrics using standardized analysis and quality control.
  • Applied Hierarchical Bayesian Regression (HBR) to model WM metrics as a function of age and sex, accounting for site effects.

Main Results:

  • Developed a large-scale normative model of WM microstructure.
  • Demonstrated the model's utility in detecting WM deviations in Alzheimer's disease, mild cognitive impairment, Parkinson's disease, and 22q11.2 deletion syndrome.
  • The HBR approach effectively models site effects, overcoming limitations of simpler harmonization techniques.

Conclusions:

  • The developed large-scale normative WM model provides a valuable common reference for clinical and research applications.
  • This model facilitates the identification of disease-specific brain alterations and aids in comparing different disorders.
  • The approach offers a robust method for analyzing multi-site dMRI data and understanding neurodevelopmental trajectories.