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Cell Migration

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.

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Related Experiment Video

Updated: Jun 9, 2025

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager

A Simple Migration/Invasion Workflow Using an Automated Live-cell Imager

Published on: February 2, 2019

A programmable platform for probing cell migration and proliferation.

Jillian Cwycyshyn, Cooper Stansbury, Walter Meixner¹

¹Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA.

APL Bioengineering

|October 31, 2024

Summary

This summary is machine-generated.

This study introduces an automated workflow using robotics for precise cell migration and proliferation assays. The system enhances reproducibility and flexibility in biological research, offering a scalable, high-throughput alternative to manual methods.

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Last Updated: Jun 9, 2025

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Area of Science:

* Biomedical Engineering
* Cell Biology
* Robotics in Research

Background:

* Advanced robotic platforms and workflow automation are transforming biological research.
* Existing methods for studying cell behavior, like manual scratch assays, often lack precision and reproducibility.
* There is a need for automated, adaptable systems to analyze cellular dynamics in vitro.

Purpose of the Study:

* To present an automated and modular workflow for exploring cell behavior in 2D culture systems.
* To demonstrate the integration of robotic platforms and workflow automation with live-cell microscopy for cell migration and proliferation assays.
* To offer a precise, reproducible, and adaptable alternative to traditional manual assays.

Main Methods:

* Integration of the BioAssemblyBot (BAB) robotic platform and BioApps workflow automater.
* Utilization of live-cell fluorescence microscopy for real-time monitoring.
* Creation of customizable cell-free zones (CFZs) using BAB's 3D-Bioprinting tool.
* In-house image processing and single-cell tracking pipeline for data analysis.

Main Results:

* Achieved precise and reproducible creation of customizable CFZs.
* Enabled hands-free, schedulable integration with live-cell monitoring systems.
* Demonstrated superior reproducibility, adaptability, and precision compared to manual scratch assays.
* Facilitated increased flexibility in wound geometry and parallel analysis of multiple experimental conditions.

Conclusions:

* The developed robotics-assisted workflow significantly enhances the study of cell migration and proliferation.
* Automation provides greater flexibility in experimental design and enables high-throughput analysis.
* The system's scalability, versatility, and experimental control make it a valuable tool for diverse research applications.