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Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1

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Current progress on the microbial therapies for acute liver failure.

Jiayuan Huang1, Tianyu Xu1, Guoqiao Quan1

  • 1Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.

Frontiers in Microbiology
|October 31, 2024
PubMed
Summary

Microbiota-based treatments show promise for acute liver failure (ALF), a severe condition with high mortality. This review explores how targeting the gut microbiome can aid in ALF prevention, treatment, and improving patient outcomes.

Keywords:
acute liver failureacute liver injuryfecal microbiota transplantationgut-liver-axismicrobiotaprobioticstype A hepatic encephalopathy

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Area of Science:

  • Hepatology
  • Microbiology
  • Gastroenterology

Background:

  • Acute liver failure (ALF) is a severe clinical condition with over 80% mortality.
  • The gut microbiota's role in ALF pathogenesis and progression is increasingly acknowledged.
  • Limited comprehensive reviews exist on microbiota-based interventions for ALF.

Purpose of the Study:

  • To critically examine microbiota-based treatments for ALF.
  • To review the mechanisms and efficacy of these treatments.
  • To assess their impact on ALF prevention, treatment, and prognosis over the last decade.

Main Methods:

  • Literature review focusing on microbiota-based interventions for ALF.
  • Analysis of studies published within the past decade.
  • Examination of mechanisms, efficacy, prevention, treatment, and prognosis.

Main Results:

  • Growing evidence supports the influence of host-microbiota interactions on ALF.
  • Microbiota-based strategies are emerging as potential therapeutic avenues.
  • Further research is needed to fully elucidate treatment efficacy and mechanisms.

Conclusions:

  • Microbiota modulation presents a promising frontier for managing ALF.
  • Understanding these interactions is crucial for developing novel therapeutic strategies.
  • This review highlights the need for continued investigation into microbiota-based ALF treatments.