The factors affecting the survivability of malignant cancer patients with deep vein thrombosis among subjects with gynecologic and non-gynecologic cancer: An ambispective cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.Cancer patients with deep vein thrombosis (DVT) face high short-term mortality. Immobilization, infection, and advanced cancer stages significantly reduce survival, underscoring the need for preventative measures.
Area Of Science
- Oncology
- Hematology
- Public Health
Background
- Gynecologic cancers are a major global health issue, with a notable incidence among women.
- Deep vein thrombosis (DVT) presents a significant challenge in cancer care, leading to poorer patient outcomes.
- This study addresses the critical need to understand factors influencing survival in cancer patients with DVT.
Purpose Of The Study
- To analyze factors impacting the survivability of cancer patients diagnosed with deep vein thrombosis (DVT).
- To specifically compare survival outcomes between gynecologic and non-gynecologic cancer patients with DVT.
Main Methods
- An ambispective cohort study involving 223 cancer patients with DVT.
- Data collected from January 2011 to August 2013, with a three-month observation period.
- Kaplan-Meier survival analysis and log-rank/Mantel-Cox tests were employed to determine statistical significance.
Main Results
- Overall, 61.4% of cancer patients with DVT experienced short-term mortality.
- Immobilization, advanced cancer stage, and infection were significant predictors of reduced survival in the overall cohort.
- Specific risk factors varied between gynecologic and non-gynecologic cancers, with pneumonia being the most common infection.
Conclusions
- Cancer patients with DVT, both gynecologic and non-gynecologic, exhibit high short-term mortality rates.
- Immobility, infection, advanced cancer stage, systemic therapy, and cancer surgery are critical risk factors affecting survival.
- Implementing secondary prophylaxis is essential for improving outcomes in this patient population.
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