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Kidney Transplant I: Introduction

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Related Experiment Video

Updated: Jul 19, 2026

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

Published on: August 10, 2015

Effective and new technologies in kidney tissue engineering.

Hossein Rayat Pisheh^1,2, Mobin Haghdel¹, Mahboube Jahangir^1,2

¹Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran.

Frontiers in Bioengineering and Biotechnology

|October 31, 2024

Summary

Kidney tissue engineering offers a promising alternative to transplantation for kidney disease. Advances in engineered structures show potential for repairing damaged kidney tissue, reducing the need for transplants.

Keywords:

3D bioprinting kidney cells kidney diseases microfluidic systems scaffold tissue engineering

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Last Updated: Jul 19, 2026

Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development

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Published on: August 10, 2015

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Isogenic Kidney Glomerulus Chip Engineered from Human Induced Pluripotent Stem Cells

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Published on: November 4, 2022

Area of Science:

Regenerative Medicine
Biotechnology
Nephrology

Background:

Kidney disease spectrum ranges from infections to chronic kidney disease, potentially leading to kidney failure.
Kidney transplantation is the definitive treatment for severe kidney failure, but faces challenges and limited availability.
Organ donation initiatives aim to increase transplantation rates, yet procedural success varies globally.

Purpose of the Study:

To review recent advances in kidney tissue engineering as a potential therapeutic approach.
To explore engineered structures that mimic the kidney's extracellular environment for cell growth.
To discuss the role of these structures in vascularization, function mimicry, and current challenges.

Main Methods:

Review of recent advances in kidney tissue engineering technologies.
Focus on engineered structures: hydrogels, electrospinning, 3D bioprinting, and microfluidic systems.
Analysis of how these structures mimic the kidney extracellular environment and support cell development.

Main Results:

Engineered kidney structures show promise in mimicking the kidney's extracellular environment.
These structures facilitate kidney cell growth, vascularization, and functional mimicry.
Kidney tissue engineering demonstrates high potential for treating kidney diseases and reducing transplant dependency.

Conclusions:

Kidney tissue engineering presents a significant potential for treating kidney diseases and decreasing reliance on transplantation.
Further research is essential to enhance biocompatibility, vascularization, and long-term performance for clinical application.
This field offers a promising avenue for regenerative medicine in nephrology.