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Updated: Jun 9, 2025

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Published on: June 9, 2023
Adiposity and Muscle Strength in Men With Prostate Cancer and Cardiovascular Outcomes.
Darryl P Leong1,2, Vincent Fradet3, Tamim Niazi4
1Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada.
Androgen deprivation therapy (ADT) for prostate cancer (PC) increases adiposity and reduces strength. High waist circumference and low strength are linked to adverse cardiovascular outcomes in PC patients.
Area of Science:
- Oncology
- Cardiology
- Endocrinology
Background:
- Limited data exist on the physical effects of androgen deprivation therapy (ADT) for prostate cancer (PC).
- The relationship between adiposity, strength, and cardiovascular outcomes in PC patients undergoing ADT is not well understood.
Purpose of the Study:
- To evaluate the association between measures of adiposity and strength with cardiovascular outcomes in PC patients.
- To characterize the 12-month changes in physical measures related to ADT use.
Main Methods:
- An international, prospective cohort study included 3,967 PC patients.
- Median follow-up was 2.3 years, with 43.6% exposed to ADT.
Main Results:
- ADT was associated with increased weight, waist circumference, and hip circumference.
- ADT led to a significant reduction in handgrip strength and a slight decrease in gait speed.
- High waist circumference and low handgrip strength were independently associated with adverse cardiovascular events.
Conclusions:
- Androgen deprivation therapy significantly impacts body composition and physical strength in prostate cancer patients.
- Increased adiposity and decreased strength are linked to a higher risk of adverse cardiovascular outcomes.
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