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Updated: May 5, 2026
07:13
An Alternative and Validated Injection Method for Accessing the Subretinal Space via a Transcleral Posterior Approach
Published on: December 7, 2016
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Investigation into the Acceptability of Moderate-to-Large Volume Subcutaneous Injections in Healthy Volunteers:
Chika Akinseye1, Andrew Fiorini2, Emily Louise Jarvis3
1GSK R&D, Discovery Medicine, Stevenage, UK.
Medical Devices (Auckland, N.Z.)
|October 31, 2024
Summary
Subcutaneous injections of larger volumes, up to 4 mL, are acceptable and tolerable for self-administration. Slower delivery rates can mitigate pain and discomfort associated with increased injection volumes.
Area of Science:
- Biomedical Engineering
- Pharmacology
- Clinical Research
Background:
- Therapeutic proteins are commonly self-administered via subcutaneous (SC) autoinjectors.
- Current autoinjectors typically have a 1 mL volume limit.
- Larger volumes may cause injection site discomfort, limiting self-administration.
Purpose of the Study:
- To evaluate the acceptability and tolerability of varying subcutaneous injection volumes and delivery rates.
- To identify optimal parameters for larger-volume SC injections.
- To assess patient comfort and safety during SC saline infusions.
Main Methods:
- A single-center, randomized, crossover study involving 24 healthy adult volunteers.
- Infusions of SC saline ranged from 1 to 5 mL at rates of 1.50-6.00 mL/min.
- Acceptability assessed via visual analogue scale (VAS) pain scores and questionnaires; tolerability evaluated for infusion leakage.
Main Results:
- Acceptable infusions included 1 mL in 10s, 4 mL in 58s, and 3 mL in 2 minutes.
- Higher volumes and rates correlated with increased VAS pain scores.
- All tested infusions remained within acceptable VAS pain criteria.
Conclusions:
- Subcutaneous injections of up to 4 mL are feasible and acceptable for self-administration.
- Slower delivery rates can manage discomfort associated with larger volumes.
- Findings support the development of autoinjectors for larger-volume drug delivery.
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