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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
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Reticular Layer
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Recombinant Fibrous Protein Gels as Rheological Modifiers in Skin Ointments.

Dustin Britton1, Jonathan Sun1,2, Hammad Ali Faizi3

  • 1Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York 11201, United States.

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Summary
This summary is machine-generated.

A novel protein hydrogel, Q5, enhances skin cream material strength at low pH. This pH-responsive rheological modifier offers improved performance in personal skin care products compared to traditional options.

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Area of Science:

  • Materials Science
  • Biotechnology
  • Cosmetic Science

Background:

  • Rheological modifiers are crucial for skin cream (SC) chassis in personal skin care products (PSCPs).
  • SC viscosity impacts PSCP effectiveness, processing, storage, and active ingredient delivery.
  • PSCPs require SCs that maintain material strength in the skin's mildly acidic environment.

Purpose of the Study:

  • To investigate a coiled-coil protein hydrogel system for pH-responsive rheological modification in PSCPs.
  • To evaluate a designed protein variant, Q5, for its ability to form hydrogels and enhance material strength at acidic pH.
  • To compare the performance of Q5 as a rheological modifier against hydroxyethyl cellulose (HEC) in a standard SC.

Main Methods:

  • Designed a coiled-coil protein hydrogel variant (Q5) with a low isoelectric point (pI).
  • Assessed Q5's solution-to-gel transition and rheological properties at varying pH levels (6.0 and 8.0).
  • Incorporated Q5 into a standard SC formulation and evaluated its material strength compared to HEC.

Main Results:

  • Q5 demonstrated a partial solution-to-gel transition at pH 6.0, functioning as a soft hydrogel.
  • Q5 uniquely increased the material strength of the SC at low pH (6.0) compared to HEC.
  • The protein-based hydrogel showed pH-dependent rheological behavior relevant to skin conditions.

Conclusions:

  • Modular protein-based coiled-coil rheological modifiers, like Q5, are suitable for PSCPs.
  • Q5 offers enhanced material strength at acidic pH, addressing a key challenge in SC formulation.
  • This protein hydrogel system presents a promising alternative to conventional rheological modifiers for personal care products.