Mangiferin: An effective agent against human malignancies

Area of Science:

• Phytochemistry and Pharmacology
• Cancer Biology and Therapeutics

Background:

• Mangiferin is a bioactive polyphenol abundant in mangoes and other fruits.
• It has garnered significant attention for its potential chemopreventive and chemotherapeutic properties against various cancers.

Purpose of the Study:

• To review the anticancer potential of mangiferin.
• To explore its mechanisms of action and efficacy in different cancer types.

Main Methods:

• Literature review of existing research on mangiferin's anticancer effects.
• Analysis of mangiferin's impact on key cancer signaling pathways (STAT3, NF-κB, PI3K/Akt, etc.).
• Examination of mangiferin's effects on cell cycle regulation and apoptosis induction.

Main Results:

• Mangiferin demonstrates therapeutic potential in rectal, prostate, ovarian, leukemia, gastric, liver, lung, cervical, breast, and brain cancers.
• It modulates crucial cancer-related signaling pathways and targets various molecules involved in cancer progression.
• Mangiferin inhibits cancer cell proliferation and development by triggering apoptosis and halting cell cycle advancement.

Conclusions:

• Mangiferin exhibits significant chemopreventive and therapeutic effects against a broad spectrum of cancers.
• Its ability to target multiple cancer pathways makes it a promising candidate for cancer treatment and prevention.
• Further clinical trials are necessary to fully establish mangiferin's role as an anticancer agent.