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Ultrasound-mediated cardiovascular thrombolysis: from Sonothrombolysis to Sonoperfusion
Zhixin Jiang1, Nan Jiang1,2,3, Zhiwen Wang1
1Echo Lab, Department of Ultrasound Imaging, Renmin Hospital of Wuhan University, PR China.
Insights
Ultrasound-mediated cardiovascular thrombolysis, including sonothrombolysis and sonoperfusion, offers a promising solution for coronary artery thromboembolism. This technique effectively clears microvascular thrombi, improving blood flow and aiding recovery from acute myocardial infarction.
Area of Science:
- Cardiovascular Medicine
- Biomedical Engineering
- Interventional Cardiology
Background:
- Coronary artery disease and acute myocardial infarction incidence are rising.
- Microcirculation thromboembolism remains a significant clinical challenge in myocardial infarction treatment.
- Early restoration of coronary blood supply via recanalization is critical.
Purpose of the Study:
- To review ultrasound-mediated cardiovascular thrombolysis for coronary artery thromboembolism.
- To explore applications, mechanisms, and research progress of sonothrombolysis and sonoperfusion.
- To highlight the potential of these techniques in improving treatment outcomes.
Main Methods:
- Review of recent advancements in ultrasound-mediated thrombolysis.
- Analysis of sonothrombolysis and sonoperfusion techniques.
- Examination of mechanisms targeting microcirculation thromboembolism.
Main Results:
- Ultrasound-mediated thrombolysis effectively addresses vascular thromboembolism, including in the microcirculation.
- Sonothrombolysis and sonoperfusion demonstrate potential for microthrombus elimination in coronary microvessels.
- These methods facilitate the recovery of terminal microcirculation function.
Conclusions:
- Ultrasound-mediated cardiovascular thrombolysis presents a novel and effective approach for coronary artery thromboembolism.
- Sonothrombolysis and sonoperfusion show significant clinical value for acute myocardial infarction treatment.
- Further research into these ultrasound-based techniques is warranted for broader clinical application.
Abstract:
The incidence of coronary artery disease has been increasing in recent years, with acute myocardial infarction as its most severe onset. The major aim for clinical treatment is to restore myocardial blood supply with the recanalization of coronary circulation as early as possible, while the still existed issue of microcirculation thromboembolism has become a serious obstacle. Thus, thrombus elimination in coronary microcirculation is crucial and essential to improve the treatment outcome of acute myocardial infarction. In recent years, from sonothrombolysis to sonoperfusion, ultrasound-mediated cardiovascular thrombolysis can effectively solve the problem of vascular thromboembolism, including microcirculation thromboembolism, and the treatment method is expected to obtain satisfied thrombolytic treatment effect with microthrombus elimination in coronary microvessels and function recovery of terminal microcirculation, which has potential clinical value for the establishment of novel treatment for coronary thromboembolism. Therefore, this paper reviews ultrasound-mediated cardiovascular thrombolysis including sonothrombolysis and sonoperfusion for the application exploration in the treatment of coronary artery thromboembolism, the mechanism of action, and its research progress.
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