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Updated: Jun 9, 2025

Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
12:00

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Olanzapine-induced mania.

Roy R Reeves1, William A McBride, Guy E Brannon

  • 1Chief of Psychiatry (116A), G. V. (Sonny) Montgomery VA Medical Center, 1500 E Woodrow Wilson Dr, Jackson, MS39216. USA.

Journal of Osteopathic Medicine
|October 31, 2024
PubMed
Summary
This summary is machine-generated.

Olanzapine effectively treats schizophrenia symptoms but can paradoxically induce mania. This case highlights a potential adverse effect requiring physician awareness during prescription.

Keywords:
Olanzapinemaniaschizophrenia

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Case Reports

Background:

  • Olanzapine is an atypical antipsychotic used for schizophrenia.
  • It targets both positive and negative symptoms of schizophrenia.
  • Adverse effects of olanzapine require ongoing investigation.

Purpose of the Study:

  • To report a case of mania secondary to olanzapine treatment.
  • To increase awareness of this potential olanzapine complication.

Main Methods:

  • Case report presentation.
  • Review of patient's clinical presentation and medication history.

Main Results:

  • A patient developed manic symptoms during olanzapine therapy.
  • The manic symptoms were considered secondary to olanzapine treatment.

Conclusions:

  • Olanzapine, despite its efficacy, carries a risk of inducing mania.
  • Clinicians should monitor for manic symptoms in patients treated with olanzapine.
  • This potential complication necessitates careful consideration in antipsychotic prescribing.