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Twin Phenomena of Hypertrophic Cardiomyopathy: A Reported Case Series

Jiang-Ting Zeng1, Ying-Ai Zhang2, Tian-Yi Ma1

  • 1Department of Cardiology, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Hainan, China.

Anatolian Journal of Cardiology
|October 31, 2024
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) in twins offers insights into genetic and environmental factors influencing this heart condition. Studying identical twins helps understand disease variability and improve personalized treatments for hypertrophic cardiomyopathy.

Area of Science:

  • Cardiovascular Genetics
  • Epigenetics
  • Human Genetics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a common genetic cardiovascular disease.
  • HCM involves asymmetric thickening of the left ventricular wall.
  • Genetic predisposition is frequent in affected families.

Purpose of the Study:

  • To review and analyze global clinical studies on twin cases of HCM.
  • To explore the genetic and epigenetic factors contributing to HCM.
  • To highlight the role of genetic screening in HCM diagnosis and management.

Main Methods:

  • Systematic review of global clinical studies focusing on HCM twin cases.
  • Analysis of genetic foundations and epigenetic influences on HCM.
  • Examination of phenotypic heterogeneity in genetically identical individuals.

Main Results:

  • Twin studies reveal complex genetic and environmental interactions in HCM.
  • Phenotypic variability exists even in genetically identical HCM cases.
  • Genetic screening is vital for early and differential diagnosis of HCM.

Conclusions:

  • Twin data enhances understanding of HCM's intricate genetic architecture.
  • Insights from HCM twins can lead to personalized management strategies.
  • Further research on twin phenomena in HCM is warranted for improved patient outcomes.

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