A Comparison of Pediatric Prehospital Opioid Encounters and Social Vulnerability

Stephen Sandelich1, Garrett Cavaliere1, Christopher Buresh2

  • 1Department of Emergency Medicine, Penn State College of Medicine, Pennsylvania State University, Hershey, Pennsylvania.

PubMed

Insights

Socioeconomic factors impact pediatric opioid emergencies. While higher socioeconomic status areas see more opioid activations, lower socioeconomic areas more frequently require naloxone, indicating care disparities.

Area of Science:

  • Public Health
  • Emergency Medicine
  • Health Disparities

Background:

  • Pediatric opioid-related emergencies are a growing public health concern.
  • Socioeconomic factors may influence the incidence and management of these emergencies.

Purpose of the Study:

  • To explore the relationship between socioeconomic factors and pediatric opioid-related emergencies.
  • To assess correlations between socioeconomic status and naloxone administration in prehospital settings.

Main Methods:

  • Retrospective analysis of the National Emergency Medical Services Information System (NEMSIS) database (January 2018 - December 2021).
  • Utilized the Social Vulnerability Index (SVI) to assess socioeconomic context.
  • Examined 7,789 pediatric opioid-related emergency medical services (EMS) activations.

Main Results:

  • Areas with higher socioeconomic status (SES) showed a greater likelihood of opioid-related activations (p=0.0112).
  • Conversely, lower SES areas (higher SVI scores) had a higher frequency of naloxone administration.
  • A significant negative linear trend was observed between improving SES and opioid-related activations.

Conclusions:

  • A significant correlation exists between area SES and pediatric opioid-related EMS activations, with an inverse relationship to naloxone administration likelihood.
  • Lower SES areas experience fewer total opioid activations but higher rates of naloxone deployment.
  • Further research is needed to understand and address disparities in opioid crisis management across socioeconomic landscapes.
Abstract

Related Concept Videos

Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
1.9K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
232
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
698
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
186
Analgesia and Pain Management01:25

Analgesia and Pain Management

Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
525
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
102