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Related Concept Videos

Diabetic Foot Ulcer01:31

Diabetic Foot Ulcer

Definition A diabetic foot ulcer (DFU) is a chronic, non-healing wound that develops in individuals with diabetes. It typically occurs on pressure-bearing areas such as the heel, metatarsal heads, or hallux, and carries a high risk of infection and amputation.Pathophysiology • The development of DFUs can be explained by four interconnected mechanisms: neuropathy, ischemia, infection, and impaired wound healing. • Neuropathy is the most common factor. Sensory neuropathy reduces pain perception,...

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Quercetin@β-Cyclodextrin Conjugated Keratin/Polyurethane Biocomposite Mats for Infected Diabetic Wound Healing.

Jie Zhang1, Xu Liu1, Yu Sun1

  • 1Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-Functional Materials, Department of Materials Science and Engineering, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, P. R. China.

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Summary

This study developed novel quercetin-loaded mats for chronic diabetic wounds. These mats improve quercetin delivery, showing strong antioxidant, antibacterial, and wound healing properties.

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing

Background:

  • Chronic diabetic wounds present significant challenges due to oxidative stress and bacterial infections.
  • Quercetin (Que) possesses potent anti-inflammatory, antioxidant, and antibacterial properties beneficial for wound treatment.
  • Existing treatments often lack sustained delivery and efficacy for complex diabetic wound environments.

Purpose of the Study:

  • To develop a novel drug delivery system for enhanced quercetin efficacy in treating chronic diabetic wounds.
  • To create a sustained-release formulation of quercetin using keratin-carboxymethyl β-cyclodextrin complexation and polyurethane electrospinning.
  • To evaluate the antioxidant, antibacterial, and wound healing capabilities of the developed quercetin-loaded mats.

Main Methods:

  • Synthesis of carboxymethyl β-cyclodextrin (CMCD) and conjugation to keratin.
  • Complexation of quercetin (Que) with Ker-CMCD to form Que@Ker-CMCD inclusion.
  • Electrospinning of Que@Ker-CMCD with polyurethane (PU) to fabricate Que@Ker-CMCD/PU mats.
  • Assessment of Que solubility, bioavailability, sustained release, antioxidant, and antibacterial activities.
  • In vitro and in vivo evaluation of the mats' effects on cell proliferation, migration, angiogenesis, and re-epithelialization.

Main Results:

  • The Que@Ker-CMCD/PU mats significantly improved quercetin's water solubility, bioavailability, and sustained release.
  • The mats demonstrated robust antioxidant and antibacterial activities against common wound pathogens.
  • Significant enhancement of cell proliferation, migration, angiogenesis, and re-epithelialization was observed.
  • Accelerated remodeling and healing of chronic diabetic wounds were achieved with the developed mats.

Conclusions:

  • The developed Que@Ker-CMCD/PU mats represent a promising therapeutic strategy for chronic diabetic wound treatment.
  • This novel approach effectively enhances quercetin delivery and leverages its multifaceted therapeutic benefits.
  • The study offers a new avenue for improving clinical outcomes in managing complex diabetic wound complications.