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Management of children with acute post-viral cough: a primary care experience with levodropropizine

Gian L Marseglia1,2, Daniele Veraldi2, Giorgio Ciprandi3

  • 1Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Minerva Pediatrics
|October 31, 2024
PubMed

Insights

Levodropropizine effectively reduces cough intensity and frequency in children suffering from acute post-viral cough (APVC). This safe treatment also improves sleep and daily activities for both children and their parents.

Area of Science:

  • Pediatrics
  • Pharmacology
  • Respiratory Medicine

Background:

  • Acute post-viral cough (APVC) significantly impacts children's quality of life.
  • Effective antitussive management is crucial for APVC.
  • Levodropropizine is recognized as a safe and effective peripheral antitussive agent.

Purpose of the Study:

  • To evaluate the efficacy and safety of levodropropizine in treating APVC in children.
  • To assess the impact of levodropropizine on cough symptoms, sleep, and daily activities.

Main Methods:

  • Retrospective observational study involving 92 children with APVC.
  • Treatment with levodropropizine for up to seven days.
  • Evaluation of cough intensity/frequency, sleep, daily activities, and adverse events.

Main Results:

  • Levodropropizine demonstrated significant reduction in cough intensity and frequency in most pediatric patients.
  • Improvements were observed in children's and parents' sleep quality and engagement in school/play activities.
  • The treatment was well-tolerated with a high level of parental satisfaction.

Conclusions:

  • Levodropropizine is an effective and safe therapeutic option for managing acute post-viral cough in pediatric populations.
  • The study supports levodropropizine's role in improving symptom burden and quality of life for children with APVC.
Abstract

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